The Nanny Trivia reveals that when it was broadcasted in Italy under the name "La Tata", Fran Fine's name was Francesca and her origins are not Jewish but Italian, from Frosinone in Ciociaria, to be more precise. "Chester" was the name of the dog which appeared in CC's dog in many episodes was really Fran Drescher's dog and its name was Chester Drescher. Lauren Lane was about to give birth for a child when CC gets sent to the sanitarium. In the first episode Fran Drescher plays a guest character named Bobbi Fleckman. In "This is Spinal Tap" episode Fran Drescher played Bobbi Flechman.

Many episodes were shelved after the network decided to have the show cancelled. When "The Nanny" was broadcast in UK, many of the reviews came for Charles Shaughnessy over his fake English accent, and were suggested to get a practice with the co-star Daniel Davis on proper English accent. Shaughnessy was a born in London and is a native Englishman. Meanwhile Daniel Davis was an American borin in Arkansas.

When the fifth season was going on, Lauren Lane and Rachel Chagall both became pregnant twice on the show. But they made them in such a way that they hid the pregnant actress behind some props or making them sit in those episodes. During the show's fifth season run, both Lauren Lane and Rachel Chagall became pregnant twice on the show. But unlike other sitcoms, that hid their pregnant actresses behind props or had them sitting. To cover Lauren Lane's possible absence during the end of her pregnancy, a storyline was introduced featuring CC taking a trip to an insane asylum.

Renee Taylor was only five year younger than Ann Morgan Guilber but she was playing as her daughter. Milhouse is the middle name of Brighton. Rachel Chagall's twins, who were born in 1999, are named Eve and Jonah; the same names as Fran and Maxwell's twins, Eve Catherine and Jonah Samuel, born on the show. The set used for the house was the exact same as the one in "Sister, Sister". The producers planned to make the main character of Fran an Italian-American; however Drescher wanted the character to remain Jewish. The character of Val Toriello, however, is Italian-American, although Rachel Chagall is actually Jewish.