The Nanny Cast consisted of various guest celebrities who made their mark in the TV series by making people to be happy by seeing the way they make humor. Some of the important guests include Pamela Anderson as Fran's nemesis Heather Biblow, Ray Charles as Yetta's fiancé Sammy, Lainie Kazan as Fran's paternal aunt Freida, and Spalding Gray as Dr. Jack Miller. Most of celebrities guest-starred in single episodes as themselves, by appearing in connection with Maxwell's business relations, such as actors and actresses Chevy Chase, Billy Ray Cyrus, Lesley-Anne Down, Erik Estrada, Dan Aykroyd, Joe Lando, Shari Lewis, Bette Midler, Jane Seymour, Cloris Leachman, Elizabeth Taylor, Jason Alexander, Lynn Redgrave and Hunter Tylo; media personalities Roger Clinton, Jr., Jay Leno, David Letterman, Jon Stewart, and Donald Trump; and musicians such as Lisa Loeb, Celine Dion, Cher, Elton John, Eartha Kitt, Patti LaBelle and Brian Setzer among many others. Actress and model Twiggyappeared came in a 1994 episode. Rapper Coolio, Whoopi Goldberg, Steve Lawrence and Rosie O'Donnell, however, guest starred as both characters and themselves in different episodes. Two-time "Survivor" Jonathan Penner appeared as Fran's former fiance, Danny Imperialli. James Marsdenappeared as Maggie's boyfriend, Eddie, and Telma Hopkins appeared as Fran's "mother" in the episode Fran's Roots.

Fran Drescher had her first feature film role in "Saturday night fever". She has acted in many other films, some of then include "American Hot Wax", "The Hollywood Knights", "Ragtime", "Gorp", "Serious Money", "Cadillac man" and "It had to be you."

Charles Shaughnessy played the role of Maxwell in The Nanny. He was born and raised in London, England. He was hailed from a show business family. His father was a script editor and a writer on "Upstairs, Downstairs" and his mother was a movie actress. He started his acting skills right from the school days and he was studying in Cambridge University. "Despite a lifelong love of the theater, I thought it was about time someone in my family did something sensible," he said. For his BBC drama series "Jury", he was awarded for his lead role in the series. Also he was one of the characters in the Television series "Partners in Crime" which was directed by Agatha Christie.